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KMID : 0604520070330020079
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Journal of the Society of Cosmetic Scientists of Korea
2007 Volume.33 No. 2 p.79 ~ p.86
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A Study on the Whitening Effect of the Oriental Medicinal Herb Forsythia suspensa Fruit as a Cosmetic Ingredient
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Lee Jung-No
Park Jae-Hee
Kim Sang-Woo
Yoo Young-Kyung
Lee Ghang-Tai
Lee Kun-Kook
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Abstract
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The aim of this study was to investigate the inhibitory effects of Forsythia suspensa fruit extracts (FSfE) () and their active component on melanogenesis. FSfE dose-dependently inhibited melanin synthesis (up to at the concentration of 1.0%) without cell cytotoxicity. We purifed one active compound from FSfE and identified its structure. It was identified as 4-[(3,4-Dimethoxyphenyl)methyl)]dihydro-3-[(4-hydroxy-3-methoxyphenyl)methyl]-2(3H)-furanone (arctigenin) by , and Mass analysis. Arctigenin also inhibited melanin synthesis in a dose dependent manner (up to at the concentration of ). In order to verify the whitening activity of the cream containing 3% FSfE, we performed the clinical test with twenty five female volunteers for 8 weeks. Bioengineering analyses and visual assessment by doctors at the initial time point and 8 weeks after applications showed that cream containing FSfE have significant whiteining effect (paired t-test). From the results, we conclude that the FSfE can be used as a useful whitening agent.
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KEYWORD
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uhiteing agent, Forsythia suspensa fruit extracts (FSfE), melanogenis, arctigenin
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